P-333 Thin endometrium, randomised clinical trial using plasma rich in growth factors
نویسندگان
چکیده
Abstract Study question Does the use of platelet growth factors instilled into thin endometrium in oestrogen-replacement treatment cycles improve endometrial thickness? Summary answer The improves What is known already Thin impairs implantation rates and IVF outcomes. To date there no effective to proliferation. PRGF-Endoret used multiple clinical indications. autologous collection (PRGF), applied area be treated, produces a controlled release molecules with regenerative capacity focus lesion. design, size, duration Prospective randomised trial determine effects PRGF-ENDORET therapy patients undergoing oestrogen for embryo transfer. Twenty-two were included from March 2018 May 2021. At end trial, complementary retrospective study was conducted analysing all treatments these without live birth(21) before after participating until December 2022. 15 embryotransfer group 27 control group. Participants/materials, setting, methods Patients IVI Bilbao clinic less than or equal 5mm 10 days treatment. PRGF prepared according technique using medical device developed by BTI Biotechnology Institute. received three instillations Endoret kitazato IUI cannula. first instillation performed situ activated coagulum 2nd 3rd PRGF-rich supernatants that previously stored at -20 °C. Main results role chance showed significant increase thickness 1.3 ± 0.67 mm compared 0.58 0.51 mm. Prior mean 4.29 0.88 4.44 0.40 After randomisation 4.87 0.76 5.74 0.87 2 pregnancies only 1 birth. shows 0.7mm post-PRGF patients. Of transfers posteriori, rate 40% 20% birth rate, biochemical miscarriage miscarriage, 0.94mm cycle. In who posteriori also 1.6mm cycle an 58.33% 33% 58.33 25% miscarriage. Comparing PRGF, statistical significance found, although 0.29mm. Limitations, reasons caution number lower initially planned, but once power adjusted, its safety efficacy demonstrated. More studies should done demonstrate when instil, how many times, transfer, it clear safe effective. Wider implications findings has been shown thickness. It could thought open door favouring receptivity therefore Trial registration 2016-001716-38
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2023
ISSN: ['1460-2350', '0268-1161']
DOI: https://doi.org/10.1093/humrep/dead093.691